Correction to Molecular Umbrella–Amphotericin B Conjugates
نویسندگان
چکیده
A ll sterols that appear on the right side of each molecular umbrella framework shown in the Abstract, Text, and Table of Contents should have been drawn with the natural stereochemistry of cholic acid shown below and not that of its enantiomer: This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
منابع مشابه
Molecular Umbrella–Amphotericin B Conjugates
A tetrawalled and an octawalled molecular umbrella conjugate of amphotericin B (AmB) have been synthesized. Both conjugates exhibit high water solubility, a low tendency to aggregate, negligible hemolytic activity at 100 μM, and an ability to release a derivative of AmB under reducing conditions that exhibits high antifungal activity. Whereas the larger, octawalled conjugate shows slight adsorp...
متن کاملTaming Amphotericin B.
A strategy is introduced for enhancing the cellular selectivity of Amphotericin B (AmB) and other classes of membrane-disrupting agents. This strategy involves attaching the agent to a molecular umbrella to minimize the disruptive power of aggregated forms. Based on this approach, AmB has been coupled to a molecular umbrella derived from one spermidine and two cholic acid molecules and found to...
متن کاملBiologically active amphotericin B-calix[4]arene conjugates.
In order to provide tools for investigations of amphotericin B ion channels, new conjugates bearing a calix[4]arene scaffold covalently linked to four amphotericin B molecules were synthesized. These macromolecules adopt a cone conformation that mimics the structure of a transmembrane pore. The antifungal activity of the conjugates 3 and 4 was superior or similar to that of native amphotericin ...
متن کاملAmphotericin B, its lipid formulations and conjugates with polymers.
The minireview is focused on novel findings concerning mechanism of action, lipid formulations, polymer conjugates, and structural modifications of amphotericin B.
متن کاملA novel strategy for bioconjugation: synthesis and preliminary evaluation with amphotericin B.
A novel linker strategy is presented based on a double reductive amination of a dialdehyde to the amine of the amphotericin B mycosamine sugar and the biological activity of a series of conjugates is compared to the native amphotericin B.
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عنوان ژورنال:
دوره 26 شماره
صفحات -
تاریخ انتشار 2015